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Research Participation Opportunities

Finding new treatments for people with disabilities

Thank you for your interest in stroke, brain injury, and spinal cord injury medical research at the Casa Colina Research Institute (CCRI). Casa Colina patients and other community members who meet certain criteria may apply to participate in our studies. The purpose of each study is to gain a better understanding of new technologies and treatment methodologies, with the goal of improving medical and rehabilitation outcomes. Below are the current studies being conducted at CCRI.


Are You Tetraplegic? Are You Interested in Controlling a Computer Using Thought?

This study seeks individuals with paralysis to control a computer using thought alone. Subjects with tetraplegia will learn to control the computer interface with the aid of the study team.

To be eligible, you must:

  • live within one hour of Casa Colina and be able to attend 3-5 times a week for at least a year (transportation available at no cost).
  • have electrodes implanted surgically and then removed after one year.

Effects of Global Brain Health on Sensorimotor Recovery After Stroke

finger pointing to brain scan

This purpose of this study is to understand how the brain recovers after neurological injury. We hope to learn how the brain adapts after a stroke and the differences in the brain that impact recovery by using brain imaging methods and noninvasive brain stimulation.

To be eligible, you must:

  • be at least 18 years old.
  • have experienced an ischemic or hemorrhagic stroke within the previous 4 weeks.
  • have written and oral proficiency in English or Spanish.

Electroencephalogram (EEG) Changes Related to Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Acute Stroke Patients: a Preliminary Study

This study aims to investigate changes in electrical brain activity related to improvements in both motor and cognitive recovery following the use of taVNS in acute stroke patients.

To be eligible, you must:

  • be between 18 to 80 years old.
  • have first time acute cerebrovascular accident (CVA) ischemic or hemorrhagic.
  • have sustained the injury within the past month.

Sleep for Stroke Management and Recovery Trial (Sleep SMART)

Eligible stroke patients will try CPAP for one night. If successful, they will be assigned to a six-month study in which one group uses CPAP with support and the other does not use CPAP.

To be eligible, you must:

  • be at least 18 years old.
  • have experienced a recent stroke or transient ischemic attack within prior 14 days to study enrollment.

Peer Support in Patients with Diabetic Foot Ulceration

This study aims to evaluate the benefits of participating in a peer support group for patients with diabetic foot ulcers to help improve ulcer care.

To be eligible, you must:

  • be at least 18 years old.
  • have had an ischemic diabetic foot ulcer within the last 6 months.

Rehabilitation to Improve Arm and Hand Function Post-Stroke

This study aims to measure the benefits of a personalized therapy program for individuals with impaired arm or hand movements, specifically focusing on improvements in motor skills and functional abilities.

To be eligible, you must:

  • be at least 18 years old.
  • have had an ischemic or hemorrhagic stroke within 1 week to 1 month prior to enrollment.
  • have hemiparesis/weakness in arm or hand.

Genetic Influences on the consciousness and functional outcome of patients with severe brain injury

DNA

The purpose of this study is to utilize genetic biomarkers to accurately identify patient outcomes and develop a personalized treatment to maximize recovery following a traumatic or non-traumatic brain injury.

To be eligible, you must:

  • be at least 18 years old.
  • have a severe acquired brain injury.
  • have no prior history of genetic, neurological, and/or psychiatric disorder.

Evaluating Perfume Bottle Designs for Individuals with Upper Extremity Deficits

The purpose of this study is to investigate the accessibility of perfume bottle designs for individuals with upper-extremity disabilities. This study seeks to provide insights and recommendations for improving the accessibility of beauty products.

To be eligible, you must:

  • be between the ages of 18 and 55 years old.
  • have minimal to moderate upper-extremity deficits.

Data-Driven User-Centered Mobility Scooter Safety Assessment

mobility scooter

This study aims to enhance the safety and usability of motorized mobility scooters. Your participation will help us gather data to achieve these goals and publish our findings.

To be eligible, you must:

  • be at least 18 years old.
  • have the ability to follow instructions in English.
  • have a lower extremity impairment.

Home Use of Brain-Computer Interface in Patients with Severe Acquired Brain Injury: A Preliminary Study

Brain

This study aims to assess the use of brain-computer interface as an effective form of communication for patients with severe acquired brain injuries and their caregiver/family.

To be eligible, you must:

  • be at least 16 years old.
  • have sustained a severe acquired brain injury at least 28 days before enrolling.
  • have language and motor difficulties impacting communication.

For more information and/or to apply to current research projects at Casa Colina, please contact 909/596-7733, ext. 2220.

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